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Lung, Glands - Cyst

Image of glandular cyst in the lung from a male B6C3F1/N mouse in a chronic study
Lung, Glands - Cyst in a male B6C3F1/N mouse from a chronic study. There is a small cyst adjacent to a bronchus (arrow).
Figure 1 of 4
Image of glandular cyst in the lung from a male B6C3F1/N mouse in a chronic study
Lung, Glands - Cyst in a male B6C3F1/N mouse from a chronic study (higher magnification of Figure 1). The cyst contains cellular debris and a few inflammatory cells and is lined by flattened epithelial cells.
Figure 2 of 4
Image of glandular cyst in the lung from a male B6C3F1/N mouse in a chronic study
Lung, Glands - Cyst, Multiple in a male B6C3F1/N mouse from a chronic study. Multiple cysts are present in the submucosa of a bronchiole (arrows).
Figure 3 of 4
Image of glandular cyst in the lung from a male B6C3F1/N mouse in a chronic study
Lung, Glands - Cyst, Multiple in a male B6C3F1/N mouse from a chronic study (higher magnification of Figure 3). The cysts are lined by low cuboidal epithelial cells and contain cell debris and inflammatory cells.
Figure 4 of 4
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comment:

Cystically dilated submucosal glands lining the bronchi ( Figure 1image opens in a pop-up window , Figure 2image opens in a pop-up window , Figure 3image opens in a pop-up window , and Figure 4image opens in a pop-up window ) are occasionally seen in rodent toxicity studies. Single ( Figure 1image opens in a pop-up window and Figure 2image opens in a pop-up window ) or multiple ( Figure 3image opens in a pop-up window and Figure 4image opens in a pop-up window ) glands may be affected. The affected glands typically contain cellular debris, glandular secretions, and inflammatory cells. The lining epithelial cells are typically attenuated and may be low cuboidal or flattened. Submucosal gland cysts may be caused by obstruction of the secretory ducts, possibly due to squamous metaplasia of the overlying mucosal epithelium that results in trapped secretions and glandular dilatation. Typically, the glandular cyst is an incidental finding with no other airway lesions and is related to aging. Chemical agents inducing cysts in the bronchial and bronchiolar glands have not been reported.

recommendation:

Lung, Glands - Cyst should be diagnosed when treatment related but not graded.

references:

NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.