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Lung - Metaplasia, Squamous - Gallery

Image of alveolar squamous metaplasia in the lung from a female Harlan Sprague-Dawley rat in a subchronic study
Lung, Alveolus - Metaplasia, Squamous in a female Harlan Sprague-Dawley rat from a subchronic study. The normal alveolar epithelium has been replaced by squamous epithelium.
Image of alveolar squamous metaplasia in the lung from a female Harlan Sprague-Dawley rat in a subchronic study
Lung, Alveolus - Metaplasia, Squamous in a female Harlan Sprague-Dawley rat from a subchronic study (higher magnification of Figure 1). The metaplastic epithelium matures normally from basal cells to squamous epithelial cells.
Image of alveolar squamous metaplasia in the lung from a female Harlan Sprague-Dawley rat in a chronic study
Lung, Alveolus - Metaplasia, Squamous in a female Harlan Sprague-Dawley rat from a chronic study. The normal alveolar epithelium has been replaced by squamous epithelium, which can be identified by the lakes of eosinophilic keratin (arrows).
Image of alveolar squamous metaplasia in the lung from a female Harlan Sprague-Dawley rat in a chronic study
Lung, Alveolus - Metaplasia, Squamous in a female Harlan Sprague-Dawley rat from a chronic study (higher magnification of Figure 3). The metaplastic epithelium is keratinized; there is also hyperplasia of the alveolar epithelium.
Image of bronchiolar squamous metaplasia in the lung from a male F344/N rat in a chronic study
Lung, Bronchiole - Metaplasia, Squamous in a male F344/N rat from an acute study. The normal bronchiolar epithelium has been replaced by squamous epithelium adjacent to an ulcer.
Image of bronchial squamous metaplasia in the lung from a male F344/N rat in a subchronic study
Lung, Bronchus - Metaplasia, Squamous in a male F344/N rat from a subchronic study. The normal bronchiolar epithelium at the bifurcation of an airway has been replaced by squamous epithelium (arrow).
Image of bronchial squamous metaplasia in the lung from a male F344/N rat in a subchronic study
Lung, Bronchus - Metaplasia, Squamous in a male F344/N rat from a subchronic study (higher magnification of Figure 6). The normal bronchiolar epithelium has been replaced by squamous epithelium (arrow).
Image of bronchiolar squamous metaplasia in the lung from a male B6C3F1/N mouse in a subchronic study
Lung, Bronchiole - Metaplasia, Squamous, Atypical from a male B6C3F1 mouse in a subchronic study. The cells on the epithelial surface are squamous, but the cells in the deeper layers are disorganized, and there is anisocytosis and anisokaryosis.