Lung - Metaplasia, Squamous - Gallery
Lung, Alveolus - Metaplasia, Squamous in a female Harlan Sprague-Dawley rat from a subchronic study. The normal alveolar epithelium has been replaced by squamous epithelium.
Lung, Alveolus - Metaplasia, Squamous in a female Harlan Sprague-Dawley rat from a subchronic study (higher magnification of Figure 1). The metaplastic epithelium matures normally from basal cells to squamous epithelial cells.
Lung, Alveolus - Metaplasia, Squamous in a female Harlan Sprague-Dawley rat from a chronic study. The normal alveolar epithelium has been replaced by squamous epithelium, which can be identified by the lakes of eosinophilic keratin (arrows).
Lung, Alveolus - Metaplasia, Squamous in a female Harlan Sprague-Dawley rat from a chronic study (higher magnification of Figure 3). The metaplastic epithelium is keratinized; there is also hyperplasia of the alveolar epithelium.
Lung, Bronchiole - Metaplasia, Squamous in a male F344/N rat from an acute study. The normal bronchiolar epithelium has been replaced by squamous epithelium adjacent to an ulcer.
Lung, Bronchus - Metaplasia, Squamous in a male F344/N rat from a subchronic study. The normal bronchiolar epithelium at the bifurcation of an airway has been replaced by squamous epithelium (arrow).
Lung, Bronchus - Metaplasia, Squamous in a male F344/N rat from a subchronic study (higher magnification of Figure 6). The normal bronchiolar epithelium has been replaced by squamous epithelium (arrow).
Lung, Bronchiole - Metaplasia, Squamous, Atypical from a male B6C3F1 mouse in a subchronic study. The cells on the epithelial surface are squamous, but the cells in the deeper layers are disorganized, and there is anisocytosis and anisokaryosis.
