Nose, Epithelium - Accumulation, Hyaline Droplet




comment:
The presence of hyaline droplets ( Figure 1



recommendation:
Because the hyaline droplets can be found in control animals, diagnosis of this as a lesion ("Accumulation, Hyaline droplet") should generally represent an increase in the size and/or number of droplets relative to controls. If there is no difference between the control and treated animals, this change need not be diagnosed. When diagnosed this lesion should be assigned a severity grade, and the epithelial type should be included in the diagnosis as the site modifier. Since this is not considered a degenerative change, any concurrent cellular degeneration should be diagnosed and graded separately.references:
Boorman GA, Morgan KT, Uraih LC. 1990. Nose, larynx, and trachea. In: Pathology of the Fischer Rat: Reference and Atlas (Boorman GA, Eustis SL, Elwell MR, eds). Academic Press, San Diego, 315-337.
Herbert RA, Leninger JR. 1999. Nose, larynx, and trachea. In: Pathology of the Mouse: Reference and Atlas (Maronpot RR, ed). Cache River Press, Vienna, IL, 259-292.
Monticello TM, Morgan KT, Uraih LC. 1990. Nonneoplastic nasal lesions in rats and mice. Environ Health Perspect 85:249-274. Full Text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1568333/
Renne R, Brix A, Harkema J, Kittel B, Lewis D, March T, Nagano K, Pino M, Rittinghausen S, Rosenbruch M, Tellier P, Wohrmann T. 2009. Proliferative and nonproliferative lesions of the rat and mouse respiratory tract. Toxicol Pathol 37(7 suppl):5S-73S. Abstract: https://www.ncbi.nlm.nih.gov/pubmed/20032296
St Clair MGB, Morgan KT. 1992. Changes in the upper respiratory tract. In: Pathology of the Aging Rat (Mohr U, Dungworth DL, Capen CC, eds). International Life Sciences Institute Press, Washington, DC, 111-127.
Web page last updated on: February 23, 2015