Eye - Phthisis Bulbi

Image of phthisis bulbi in the eye from a female B6C3F1 mouse in a chronic study
Eye - Phthisis bulbi in a female B6C3F1 mouse from a chronic study. Phthisis bulbi ("end-stage" eye) is characterized by prominent shrinkage of the globe with marked structural displacement and disorganization
Figure 1 of 4
Image of phthisis bulbi in the eye from a female B6C3F1 mouse in a chronic study
Eye - Phthisis bulbi in a female B6C3F1 mouse from a chronic study. The globe is shrunken with marked structural displacement and disorganization.
Figure 2 of 4
Image of phthisis bulbi in the eye from a female B6C3F1 mouse in a chronic study
Eye - Phthisis bulbi in a female B6C3F1 mouse from a chronic study. There is marked shrinkage of the globe (arrow) with marked structural displacement and disorganization.
Figure 3 of 4
Image of phthisis bulbi in the eye from a female B6C3F1 mouse in a lifetime study
Eye - Phthisis bulbi in a female B6C3F1 mouse from a lifetime study. The globe is shrunken (arrow) with marked structural displacement and disorganization and compressed by a large Harderian gland carcinoma (H).
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comment:

Phthisis bulbi ( Figure 1image opens in a pop-up window , Figure 2image opens in a pop-up window , Figure 3image opens in a pop-up window , and Figure 4image opens in a pop-up window ) is the diagnostic term used for the "end-stage" eye morphology resulting from severe injury from various causes, such as trauma, inflammation, excess exposure to ionizing radiation or ambient light, or physical compression by space-occupying orbital masses, such as neoplasms of the Harderian gland ( Figure 4image opens in a pop-up window ). Phthisis bulbi is characterized by prominent shrinkage of the globe with marked displacement and disorganization of ocular structures.

recommendation:

Phthisis bulbi should be diagnosed as present without assignment of a severity grade. Changes in the various ocular subtopographies should not be diagnosed separately as they are included in the collective diagnostic term "phthisis bulbi." If an inciting cause (e.g., a foreign body) is present, it should be diagnosed separately, and the association between the two lesions should be described in the narrative.

references:

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Abstract: http://ntp.niehs.nih.gov/go/6963

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National Toxicology Program. 1992. NTP TR-411. Toxicology and Carcinogenesis Studies of C.I. Pigment Red 23 (CAS No. 6471-49-4)in F344 Rats and B6C3F1 Mice (Feed Studies). NTP, Research Triangle Park, NC.
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Abstract: http://tpx.sagepub.com/content/19/2/148.short

Takase H, Yu C-R, Ham D-I, Chan C-C, Chen J, Vistica BP, Warousek EF, Durum SK, Egwuagu CE, Gery I. 2006. Inflammatory processes triggered by TCR engagement or by local cytokine expression: Differences in profiles of gene expression and infiltrating cell populations. J Leukocyte Biol 80:538-545.
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Whittum JA, McCulley JP, Niederkorn JY, Streilein JW. 1984. Ocular disease induced in mice by anterior chamber inoculation of herpes simplex virus. Invest Ophthalmol Vis Sci 25:1065-1073.
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Yoshitomi K, Boorman GA. 1990. Eye and associated glands. In: Pathology of the Fischer Rat: Reference and Atlas (Boorman GA, Eustis SL, Elwell MR, Montgomery CA, MacKenzie WF, eds). Academic Press, San Diego, CA, 239-260.
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