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  • Harderian Gland - Cyst

    Image of cyst in the Harderian gland from a male B6C3F1 mouse in a chronic study
    Harderian gland - Cyst in a male B6C3F1 mouse from a chronic study. Cysts (arrow) consisting of large, widely distended, multiloculated spaces filled with variable amounts of pale amorphous secretory material.
    Figure 1 of 2
    Image of cyst in the Harderian gland from a male B6C3F1 mouse in a chronic study
    Harderian gland - Cyst in a male B6C3F1 mouse from a chronic study (higher magnification of Figure 1). The epithelium lining the cyst is flattened.
    Figure 2 of 2
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    comment:

    Harderian gland cysts are large, widely distended, single to multiloculated spaces ( Figure 1image opens in a pop-up window and Figure 2image opens in a pop-up window ) lined by flattened epithelium and filled with variable amounts of pale amorphous secretory material. Typically, cysts have greater diameter than dilated gland alveoli. Harderian gland cysts are uncommon.

    recommendation:

    Harderian gland cysts should be diagnosed as present (without assignment of a severity grade). Secondary inflammation should not be diagnosed separately (unless warranted by severity).

    references:

    Botts S, Jokinen M, Gaillard ET, Elwell MR, Mann PC. 1999. Salivary, Harderian, and lacrimal glands. In: Pathology of the Mouse: Reference and Atlas (Maronpot RR, Boorman GA, Gaul BW, eds). Cache River Press, Vienna, IL, 49-79.
    Abstract: http://www.cacheriverpress.com/books/pathmouse.htm

    National Toxicology Program. 1983. NTP TR-244. Toxicology and Carcinogenesis Studies of a Polybrominated Biphenyl Mixture (Firemaster FF-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies). NTP, Research Triangle Park, NC.
    Abstract: http://ntp.niehs.nih.gov/go/7095