U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Skip to Main Navigation
Skip to Page Content
Skip to Atlas Navigation

Harderian Gland - Cyst

Image of cyst in the Harderian gland from a male B6C3F1 mouse in a chronic study
Harderian gland - Cyst in a male B6C3F1 mouse from a chronic study. Cysts (arrow) consisting of large, widely distended, multiloculated spaces filled with variable amounts of pale amorphous secretory material.
Figure 1 of 2
Image of cyst in the Harderian gland from a male B6C3F1 mouse in a chronic study
Harderian gland - Cyst in a male B6C3F1 mouse from a chronic study (higher magnification of Figure 1). The epithelium lining the cyst is flattened.
Figure 2 of 2
next arrow
View all images

comment:

Harderian gland cysts are large, widely distended, single to multiloculated spaces ( Figure 1image opens in a pop-up window and Figure 2image opens in a pop-up window ) lined by flattened epithelium and filled with variable amounts of pale amorphous secretory material. Typically, cysts have greater diameter than dilated gland alveoli. Harderian gland cysts are uncommon.

recommendation:

Harderian gland cysts should be diagnosed as present (without assignment of a severity grade). Secondary inflammation should not be diagnosed separately (unless warranted by severity).

references:

Botts S, Jokinen M, Gaillard ET, Elwell MR, Mann PC. 1999. Salivary, Harderian, and lacrimal glands. In: Pathology of the Mouse: Reference and Atlas (Maronpot RR, Boorman GA, Gaul BW, eds). Cache River Press, Vienna, IL, 49-79.
Abstract: http://www.cacheriverpress.com/books/pathmouse.htm

National Toxicology Program. 1983. NTP TR-244. Toxicology and Carcinogenesis Studies of a Polybrominated Biphenyl Mixture (Firemaster FF-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies). NTP, Research Triangle Park, NC.
Abstract: https://ntp.niehs.nih.gov/go/7095

Back to top

Web page last updated on: October 24, 2014