Harderian Gland - Dilation
comment:Harderian gland dilation is characterized by focal clusters of Harderian gland alveoli with dilated lumens lined by slightly flattened epithelial cells ( Figure 1 and Figure 2 ); there is little if any associated interstitial fibrosis. Some dilated gland alveoli also exhibit intraluminal porphyrin pigment aggregates. Such dilatation is a common spontaneous finding in the Harderian glands of rats and mice but can also be induced by administration of various chemical agents.
recommendation:Harderian gland dilation should be diagnosed only if there are treatment-related differences in incidence and/or severity. When diagnosed, it should be assigned a severity grade. The associated porphyrin pigment should not be diagnosed separately (unless warranted by severity), but should be described in the pathology narrative.
Botts S, Jokinen M, Gaillard ET, Elwell MR, Mann PC. 1999. Salivary, Harderian, and lacrimal glands. In: Pathology of the Mouse: Reference and Atlas (Maronpot RR, Boorman GA, Gaul BW, eds). Cache River Press, Vienna, IL, 49-79. Abstract: http://www.cacheriverpress.com/books/pathmouse.htm
Iwai H, Tagawa Y, Hayasaka I, Hayasaka I, Yanai T, Masegi T. 2000. Effects of atropine sulfate on rat Harderian glands: Correlation between morphological changes and porphyrin levels. J Toxicol Sci 25:151-159. Abstract: http://europepmc.org/abstract/MED/10987121
National Toxicology Program. 1993. NTP TR-402. Toxicology and Carcinogenesis Studies of Furan (CAS No. 110-00-9) in F344 Rats and B6C3F1 Mice (Gavage Studies). NTP, Research Triangle Park, NC. Abstract: http://ntp.niehs.nih.gov/go/12255
National Toxicology Program. 1999. NTP TR-469. Toxicology and Carcinogenesis Studies of AZT (CAS No. 30516-87-1) and AZT/α-Interferon A/D in B6C3F1 Mice (Gavage Studies). NTP, Research Triangle Park, NC. Abstract: http://ntp.niehs.nih.gov/go/6082
Satoh Y, Ishikawa K, Oomori Y, Takede S, Ono K. 1992. Secretion mode of the Harderian gland of rats after stimulation by cholinergic secretagogues. Acta Anat 143:7-13. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/1350161
Yoshitomi K, Boorman GA. 1990. Eye and associated glands. In: Pathology of the Fischer Rat: Reference and Atlas (Boorman GA, Eustis SL, Elwell MR, Montgomery CA, MacKenzie WF, eds). Academic Press, San Diego, CA, 239-260. Abstract: http://www.ncbi.nlm.nih.gov/nlmcatalog/9002563
Web page last updated on: October 24, 2014