Harderian Gland – Hemorrhage
comment:Harderian gland hemorrhage consists of variable numbers of extravasated blood cells in the gland interstitium and/or alveoli ( Figure 1 and Figure 2 ). A common cause is trauma from retro-orbital bleeding procedures.
recommendation:Harderian gland hemorrhage should be diagnosed with assignment of a severity grade. Hemorrhage secondary to other lesions (e.g., inflammation) should not be diagnosed separately unless warranted by severity.
Botts S, Jokinen M, Gaillard ET, Elwell MR, Mann PC. 1999. Salivary, Harderian, and lacrimal glands. In: Pathology of the Mouse: Reference and Atlas (Maronpot RR, Boorman GA, Gaul BW, eds). Cache River Press, Vienna, IL, 49-79. Abstract: http://www.cacheriverpress.com/books/pathmouse.htm
National Toxicology Program. 1989. NTP TR-352. Toxicology and Carcinogenesis Studies of N-Methylolacrylamide (CAS No. 924-42-5) in F344/N Rats and B6C3F1 Mice (Gavage Studies). NTP, Research Triangle Park, NC. Abstract: http://ntp.niehs.nih.gov/go/6965
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