Special Senses System

Harderian Gland - Hemorrhage

Narrative
Comment:
Harderian gland hemorrhage consists of variable numbers of extravasated blood cells in the gland interstitium and/or alveoli (Figure 1 and Figure 2). A common cause is trauma from retro-orbital bleeding procedures.
Recommendations:
Harderian gland hemorrhage should be diagnosed with assignment of a severity grade. Hemorrhage secondary to other lesions (e.g., inflammation) should not be diagnosed separately unless warranted by severity.
References:

Botts S, Jokinen M, Gaillard ET, Elwell MR, Mann PC. 1999. Salivary, Harderian, and lacrimal glands. In: Pathology of the Mouse: Reference and Atlas (Maronpot RR, Boorman GA, Gaul BW, eds). Cache River Press, Vienna, IL, 49-79.

Abstract: http://www.cacheriverpress.com/books/pathmouse.htm

National Toxicology Program. 1989. NTP TR-352. Toxicology and Carcinogenesis Studies of N-Methylolacrylamide (CAS No. 924-42-5) in F344/N Rats and B6C3F1 Mice (Gavage Studies). NTP, Research Triangle Park, NC.

Abstract: https://ntp.niehs.nih.gov/go/6965
  • Image of hemorrhage in the Harderian gland from a male F344/N rat in a chronic study

    Harderian gland - Hemorrhage in a male Fischer 344\N rat from a chronic study. There are abundant extravasated blood cells in the Harderian gland.

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<p>Harderian gland - Hemorrhage in a male Fischer 344\N rat from a chronic study. There are abundant extravasated blood cells in the Harderian gland.</p>

Harderian gland - Hemorrhage in a male Fischer 344\N rat from a chronic study. There are abundant extravasated blood cells in the Harderian gland.
<p>Harderian gland - Hemorrhage in a male Fischer 344\N rat from a chronic study (higher magnification of Figure 1). Higher magnification of the extravasated red blood cells.</p>

Harderian gland - Hemorrhage in a male Fischer 344\N rat from a chronic study (higher magnification of Figure 1). Higher magnification of the extravasated red blood cells.

Author

Margarita M. Gruebbel, DVM, PhD, DACVP
Senior Pathologist
Experimental Pathology Laboratories, Inc.
Research Triangle Park, NC

Reviewers

Ruth E. Hurley, DVM, PHD, DACVP
Senior Veterinary Pathologist
Huntingdon Life Sciences
North Brunswick, NJ

Robert R. Maronpot, DVM, MS, MPH, DACVP, DABT, FIATP
Senior Pathologist
Experimental Pathology Laboratories, Inc.
Research Triangle Park, NC