Zymbal’s Gland - Hypertrophy

Zymbal's gland - Hypertrophy in a male F344/N rat from a chronic study. There are clusters of enlarged epithelial cells (arrows).
Figure 1 of 3

Zymbal's gland - Hypertrophy in a male F344/N rat from a chronic study (higher magnification of Figure 1). Epithelial cells are enlarged by increased amounts of pale eosinophilic, foamy or lacy cytoplasm (arrow).
Figure 2 of 3
comment:
Zymbal's gland hypertrophy ( Figure 1


recommendation:
Zymbal's gland hypertrophy should be diagnosed and assigned a severity grade when present as a treatment-related effect.references:
Copeland-Haines D, Eustis SL. 1990. Specialized sebaceous glands. In: Pathology of the Fischer Rat: Reference and Atlas (Boorman GA, Eustis SL, Elwell MR, Montgomery CA, MacKenzie WF, eds). Academic Press, San Diego, CA, 279-294. Abstract: https://www.ncbi.nlm.nih.gov/nlmcatalog/9002563
National Toxicology Program. 1990. NTP TR-372. Toxicology and Carcinogenesis Studies of 3,3'-Dimethoxybenzidine Dihydrochloride (CAS No. 20325-40-0) in F344/N Rats (Drinking Water Studies). NTP, Research Triangle Park, NC. Abstract: https://ntp.niehs.nih.gov/go/8884
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