Zymbal’s Gland - Hypertrophy
comment:Zymbal's gland hypertrophy ( Figure 1 , Figure 2 , and Figure 3 ) is characterized by clusters of enlarged epithelial cells that may or may not be increased in number but that are enlarged by increased amounts of pale eosinophilic, foamy or lacy cytoplasm.
recommendation:Zymbal's gland hypertrophy should be diagnosed and assigned a severity grade when present as a treatment-related effect.
Copeland-Haines D, Eustis SL. 1990. Specialized sebaceous glands. In: Pathology of the Fischer Rat: Reference and Atlas (Boorman GA, Eustis SL, Elwell MR, Montgomery CA, MacKenzie WF, eds). Academic Press, San Diego, CA, 279-294. Abstract: http://www.ncbi.nlm.nih.gov/nlmcatalog/9002563
National Toxicology Program. 1990. NTP TR-372. Toxicology and Carcinogenesis Studies of 3,3'-Dimethoxybenzidine Dihydrochloride (CAS No. 20325-40-0) in F344/N Rats (Drinking Water Studies). NTP, Research Triangle Park, NC. Abstract: http://ntp.niehs.nih.gov/go/8884
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