Special Senses System

Zymbal's Gland - Hypertrophy

Narrative
Comment:
Zymbal's gland hypertrophy (Figure 1, Figure 2, and Figure 3) is characterized by clusters of enlarged epithelial cells that may or may not be increased in number but that are enlarged by increased amounts of pale eosinophilic, foamy or lacy cytoplasm.
Recommendations:
Zymbal's gland hypertrophy should be diagnosed and assigned a severity grade when present as a treatment-related effect.
References:

Copeland-Haines D, Eustis SL. 1990. Specialized sebaceous glands. In: Pathology of the Fischer Rat: Reference and Atlas (Boorman GA, Eustis SL, Elwell MR, Montgomery CA, MacKenzie WF, eds). Academic Press, San Diego, CA, 279-294.

Abstract: https://www.ncbi.nlm.nih.gov/nlmcatalog/9002563

National Toxicology Program. 1990. NTP TR-372. Toxicology and Carcinogenesis Studies of 3,3'-Dimethoxybenzidine Dihydrochloride (CAS No. 20325-40-0) in F344/N Rats (Drinking Water Studies). NTP, Research Triangle Park, NC.

Abstract: https://ntp.niehs.nih.gov/go/8884
  • Image of hypertrophy in the Zymbal's gland from a male F344/N rat in a chronic study
    Zymbal's gland - Hypertrophy in a male F344/N rat from a chronic study. There are clusters of enlarged epithelial cells (arrows).
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Zymbal's gland - Hypertrophy in a male F344/N rat from a chronic study. There are clusters of enlarged epithelial cells (arrows).
Zymbal's gland - Hypertrophy in a male F344/N rat from a chronic study. There are clusters of enlarged epithelial cells (arrows).
Zymbal's gland - Hypertrophy in a male F344/N rat from a chronic study (higher magnification of Figure 1). Epithelial cells are enlarged by increased amounts of pale eosinophilic, foamy or lacy cytoplasm (arrow).
Zymbal's gland - Hypertrophy in a male F344/N rat from a chronic study (higher magnification of Figure 1). Epithelial cells are enlarged by increased amounts of pale eosinophilic, foamy or lacy cytoplasm (arrow).
Zymbal's gland - Hypertrophy in a female F344/N rat from a chronic study (higher magnification of Figure 1). Hypertrophic epithelial cells (arrow) are enlarged by increased amounts of pale eosinophilic, foamy or lacy cytoplasm.
Zymbal's gland - Hypertrophy in a female F344/N rat from a chronic study (higher magnification of Figure 1). Hypertrophic epithelial cells (arrow) are enlarged by increased amounts of pale eosinophilic, foamy or lacy cytoplasm.

Author

Margarita M. Gruebbel, DVM, PhD, DACVP
Senior Pathologist
Experimental Pathology Laboratories, Inc.
Research Triangle Park, NC

Reviewers

Ruth E. Hurley, DVM, PHD, DACVP
Senior Veterinary Pathologist
Huntingdon Life Sciences
North Brunswick, NJ

Robert R. Maronpot, DVM, MS, MPH, DACVP, DABT, FIATP
Senior Pathologist
Experimental Pathology Laboratories, Inc.
Research Triangle Park, NC