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Kidney - Metaplasia, Osseous

Image of metaplasia, osseous in the kidney from a female B6C3F1 mouse in a chronic study
Kidney - Metaplasia, Osseous in a female B6C3F1 mouse from a chronic study. An area of mature bone and associated hematopoietic cells is present in the renal cortex.
Figure 1 of 2
Image of metaplasia, osseous in the kidney from a male B6C3F1 mouse in a chronic study
Kidney - Metaplasia, Osseous in a male B6C3F1 mouse from a chronic study. An area of mature bone is present in the cortex.
Figure 2 of 2
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comment:

Osseous metaplasia is characterized by mature-appearing bone in the renal parenchyma. It is usually noted as a focal lesion in the cortex and is regarded as a spontaneous lesion of no pathologic significance. Osseous metaplasia may vary in size, and hematopoietic cells may be present in larger lesions ( Figure 1image opens in a pop-up window and Figure 2image opens in a pop-up window ). Osseous metaplasia needs to be distinguished from mineralization.

recommendation:

Osseous metaplasia should be recorded but need not be graded.

related links:

Kidney - Ectopic Tissue

references:

Montgomery CA, Seely JC. 1990. Kidney. In: Pathology of the Fischer Rat: Reference and Atlas (Boorman GA, Eustis SL, Elwell MR, Montgomery CA, MacKenzie WF, eds). Academic Press, San Diego, 127-153.
Abstract: http://www.ncbi.nlm.nih.gov/nlmcatalog/9002563

NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.