U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Skip to Main Navigation
Skip to Page Content
Skip to Atlas Navigation

Kidney, Papilla, Epithelium - Hyperplasia

Image of papilla epithelium hyperplasia in the kidney from a male F344/N rat in a chronic study
Kidney, Papilla, Epithelium - Hyperplasia in a male F344/N rat from a chronic study. The epithelium is thickened (arrows), and there are large clear spaces within the hyperplastic epithelium.
Figure 1 of 2
Image of papilla epithelium hyperplasia in the kidney from a male F344/N rat in a chronic study
Kidney, Papilla, Epithelium - Hyperplasia in a male F344/N rat from a chronic study. A small focus of hyperplastic surface epithelial cells lines the renal papilla (arrows).
Figure 2 of 2
next arrow
View all images

comment:

Hyperplasia of the surface epithelium of the renal papilla can range from thickening of the epithelium ( Figure 1image opens in a pop-up window , arrows) to variably sized outgrowths of the epithelium with clear spaces amid the cells ( Figure 2image opens in a pop-up window ). Sometimes, these spaces contain eosinophilic material or cells. This lesion is commonly observed with advanced chronic progressive nephropathy (see Kidney - Nephropathy, Chronic Progressive).

recommendation:

Hyperplasia of the renal papillary epithelium should be diagnosed and given a severity grade whenever present.

related links:

Kidney, Urothelium - Hyperplasia

references:

Frazier KS, Seely JC, Hard GC, Betton G, Burnett R, Nakatsuji S, Nishikawa A, Durchfeld-Meyer B, Bube A. 2012. Proliferative and non-proliferative lesions in the rat and mouse urinary system. Toxicol Pathol 40:14S-86S.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/22637735

McInnes EF. 2012. Wistar and Sprague-Dawley rats. In: Background Lesions in Laboratory Animals: A Color Atlas. Saunders Elsevier, Edinburg, 29.
Abstract: http://www.sciencedirect.com/science/book/9780702035197

Back to top

Web page last updated on: October 28, 2014