Tooth, Ameloblast - Metaplasia, Squamous


comment:
Squamous metaplasia can be seen following injury to the ameloblasts. While atrophy is characterized by decreased cytoplasm (shortening of individual ameloblasts), squamous metaplasia is characterized by loss of the columnar layer of ameloblasts and replacement by squamous epithelium ( Figure 2

recommendation:
Squamous metaplasia of the ameloblasts should be diagnosed and graded whenever present. Severity grading for squamous metaplasia is based on the extent of the lesion and the number of layers of squamous cells in the lesion.references:
Brown HR, Hardisty JF. 1990. Oral cavity, esophagus and stomach. In: Pathology of the Fischer Rat (Boorman GA, Montgomery CA, MacKenzie WF, eds). Academic Press, San Diego, CA, 9-30. Abstract: https://www.ncbi.nlm.nih.gov/nlmcatalog/9002563
Fletcher AM, Bregman CL, Woicke J, Salcedo TW, Zidell RH, Janke HE, Fang H, Janusz WJ, Schlze GE, Mense MG. 2010. Incisor degeneration in rats induced by vascular endothelial growth factor/fibroblast growth factor receptor tyrosine kinase inhibition. Toxicol Pathol 38:267-279. Abstract: https://www.ncbi.nlm.nih.gov/pubmed/20100840
National Toxicology Program. 1996. NTP TR-393. Toxicology and Carcinogenesis Studies of Sodium Fluoride (CAS No. 7681-49-4) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies). NTP, Research Triangle Park, NC. Abstract: https://ntp.niehs.nih.gov/go/12237
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