Tooth, Ameloblast - Metaplasia, Squamous
comment:Squamous metaplasia can be seen following injury to the ameloblasts. While atrophy is characterized by decreased cytoplasm (shortening of individual ameloblasts), squamous metaplasia is characterized by loss of the columnar layer of ameloblasts and replacement by squamous epithelium ( Figure 2 and Figure 4 , arrows).
recommendation:Squamous metaplasia of the ameloblasts should be diagnosed and graded whenever present. Severity grading for squamous metaplasia is based on the extent of the lesion and the number of layers of squamous cells in the lesion.
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National Toxicology Program. 1996. NTP TR-393. Toxicology and Carcinogenesis Studies of Sodium Fluoride (CAS No. 7681-49-4) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies). NTP, Research Triangle Park, NC. Abstract: http://ntp.niehs.nih.gov/go/12237
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